Without Immunity, We’RE JUST BAGS OF NUTRIENTS!

Antimicrobial Agents  - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

 Modes of action Interference with: 

cell wall synthesis 

protein synthesis 

nucleic acid synthesis 

plasma membrane integrity 

metabolic pathway 

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis 

The Beta-lactam Family 

The Glycopeptides 

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids.  Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams 

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis. 

Glycopeptides 

Polypeptide agents - basic structural elements amino acids 

Vancomycin: 

complexes with peptide portion of peptidoglycan’s precursor units 

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses:  serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve 

hearing loss (ototoxicity) 

“Red man/neck” syndrome - rash on face, neck, upper torso 

Gram Negative Aerobic Rods Mnemonic

MICROBIOLOGY MNEMONIC 

BRUno, FRANCISco & COnstantine are BORing PSEUDO LEGIONnaires

Brucella sp 

Francisella tularensis 

Coxiella burnetti

Bortedella pertusis

Pseudomona aeuroginosa

Legionella pneumophila

(Day 4/100 days of productivity) - Haemophilus Influenzae card!

Today was mostly spent working on research, textbooks, but and making flashcards like this for microbiology!

Tick vectors

Ixodes:

Lyme disease: Borrelia burgdorferi 

Babesiosis: Babesia microti

Granulocytic Erlichiosis: Erlichia phagocytophila

Dermacentor: 

Tularemia: Francisella tularensis

Rocky Mountain Spotted Fever: Ricketsia rickettsii

Colorado Tick Fever: CTFVirus (Reovirus)

Amblyomma (lone star tick)

Monocytic Erlichiosis: Erlichia chaffeensis

New background! Download higher quality photo here!

https://drive.google.com/file/d/1F5SlJmB8YiNNtGuKrc-QtMnrrjZ1tOHL/view?usp=sharing

it’s technically kinda busy work but i still love it

Hey, I’m back with another masterpost. I decided to include some of my tips.

Use the forest app to keep you off your phone, your phone is a distractions you face when studying

Try making a to-do list to plan out how much time you take to do each task so you keep track of time

Set rewards i.e. if I finish this task at 9am instead of 9.30am, I’ll watch my favourite tv show for 1 hour instead of 30mins.

How to be disciplined

I guess this is pretty much like a habit. So try to maybe start small, i.e. study 10 mins each day and gradually increase the time limit if you feel comfortable doing so. The reason I chose 10 mins is because it seems like a very short period of time so it’s easier for you to get to work.

How to manage studies with social media

Always set a time period for your school work. For example, after 30 minutes of browsing through your social media, force yourself to do a piece of school work. That way, you will still get work done instead of browsing through your social media all day long.

If you realise on tumblr, I don’t come up with an original post every day and I tend to reblog my old post or queue others posts so don’t stress too much on coming up with a post. For instagram, you could try to take pictures all during the weekend, so you don’t have to stress taking them after school, etc.  But it is important to always put studies first before your social media.

Consider switching off your phone or even deleting your social media apps or deactivating them during exams period if they are really getting in the way of your studies.

Plan

How to schedule your day when you’re unemployed by @businessinsider

How to stick your plans by @cafeinated

How to make and stick to your study plan by @sherlocks-study

Create long term study plan + how to stick to study routines by @studyforyourself

Start

How to start studying by @studylou

How to start working when you really don’t feel like it? by @studentstoolbox

What to do when you really don’t want to study by @yeon-studies

How to stop scrolling through tumblr for 3 hours when you have work by @effectivestudies

More productive

How to become more productive by @to-work-or-not-to-work

How I increased my productivity by 3 times by @brbimstudying

4 secrets to efficiency

The ivy lee method for peak productivity by @harcules

General

How to study as a busy student by @julstudies

Use studyblr to become productive by @determinationandcaffeine

Take a productive break by @thestudycoffee

5 things everyone should do on sunday night by @staedtlers-and-stabilos

Productivity 101 by @lets-study-together

The no bullshit guide to getting your shit together: for the lazy student by @knoweldge

Habits

8 morning habits for productivity by @eintsein

The 8 habits of highly productive people by @medicinasanguis

Habits of highly effective people by @onlinecounsellingcollege

6 habits for maximum productivity by @livingthatlibrarylifestyle

How to develop self discipline

How to wake up earlier by @gurl

Motivation

Focus and motivation by @katsdesk

Whenever you’re feeling unmotivated and sleepy by @evergreenstudies

How to stay awake while studying without caffeine by @getshitsdone

How to be productive + motivated on weekends by @studywithinspo

Procrastination

Types of procrastination and how to deal with them by @emmastudies

How to stop procrastination

How to stop procrastinating by @cutestudystuff

15 productivity hacks for procrastinators by @engincrd

Unconventional methods to beat procrastination by @hawkestudies

What type of procrastinator are you by @b-uwu-ng

Eliminating procrastination and distraction during a study session by @simply-study

Productive when travelling

productive commutes by @universi-tea

productivity on road trips by @intellectys

Tips

7 productivity tips by @simmonestudies

10 small tips to improve your productivity

The dutch student’s productivity tips by @thedutchstudent

My top 10 tips for productivity by @lovelybluepanda

21 tips to become the most productive person you know by @studying-towards-success

Tips and tricks for busy students by @roeum

Time management

Managing time

How to manage time by @solar-citrus

How i manage my time by @pensandmachines

Time management 

Tips

Time management tips by @365text

Time management tips for busy students

Time management tips

Tips for time management by @holocrams

26 time management hacks I’d wish I’d known at 20 by @geekvitamin

How to make the best use of your time by @tbhstudying

5 ways to manage your time efficiently by @quadrtics

Printables

Daily planner by @arystudies

Weekly planner by @studyblrbunny

Productivity printables by @thearialligraphyproject

Habit tracker by @candydsgn

Schedules by @kouiro

Bullet journal

My 2016 bullet journal setup

Sounds

Study sounds by @studyquill

Other masterposts by me

Printables

College

Apps for students

Note taking

Math

Bullet journal

icon credit to @nerdastically

Leukocyes (WBCs) & Defence

A summary

Neutrophils -  non-specific defence against bacteria and fungi

Eosinophils -Defence against parasites; dampen allergic response

Basophils  - Anaphylactic & inflammation response

Monocytes - Mature into macrophages, engulf foreign substances;  remove aged RBCs and other debris

Lymphocyes - Recognise antigens, various roles

Antibodies (Human)

The ‘foot’ (bottom) of the antibody is known as the Fc fragment - binds to cells, binds to complement = effector function (kills or removes antigen)

The top (antigen binding) is the Fab fragment

Chains are held together with disulphide binds

Associated molecules allow intracellular signalling 

Normally 3X constant heavy chain domains per chain and a hinge region (except μ and ε which have 4 and no hinge region)

Classes of Immunoglobulins

The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD and IgE,  distinguished by the type of heavy chain found in the molecule. 

IgG - gamma-chains

IgMs - mu-chains

IgAs - alpha-chains

IgEs - epsilon-chains

IgDs - delta-chains.

Differences in heavy chain polypeptides allow different types of immune responses. The differences are found primarily in the Fc fragment. There are only two main types of light chains: kappa (κ) and lambda (λ), and any antibody can have any combination of these 2 (variation).

IgG 

monomer

Gamma chains

70-85% of Ig in human serum. 

secondary immune response 

only class that can cross the placenta - protection of the newborn during first 6 months of life

principle antibody used in immunological research and clinical diagnostics

21 day half life

Hinge region (allows it to make Y and T shapes - increasing chance of being able to bind to more than one site)

Fc strongly binds to Fcγ receptor on phagocyte - opsono-phagocytosis

Activates complement pathway

IgM

Serum = pentamer 

Primary immune responses - first Ig to be synthesised

complement fixing 

10% of serum Ig 

also expressed on the plasma membrane of B lymphocytes as a monomer - B cell antigen receptor

H chains each contain an additional hydrophobic domain for anchoring in the membrane

Monomers are bound together by disulfide bonds and a joining (J) chain.

Each of the five monomers = two light chains (either kappa or lambda) and two mu heavy chains.

heavy chain = one variable and four constant regions (no hinge region)

can cause cell agglutination as a result of recognition of epitopes on invading microorganisms. This antibody-antigen immune complex is then destroyed by complement fixation or receptor mediated endocytosis by macrophages.

In humans there are four subclasses of IgG: IgG1, IgG2, IgG3 and IgG4. IgG1 and IgG3 activate complement.

IgD 

B cell receptor

<1% of blood serum Ig

has tail pieces that anchor it across B cell membrane

forms an antigen specific receptor on mature B cells - consequently has no known effector function (don’t kill antigens, purely a receptor) (IgM as a monomer can also do this)

IgE 

Extra rigid central domain

has the most carbohydrates

IgE primarily defends against parasitic invasion and is responsible for allergic reactions.

basophils and tissue mast cells express very high affinity Fc receptors for IgE - mast cells then release histamine

so high that almost all IgE is bound

sensitizes (activates) mucosal cells and tissues 

protects against helminth parasites

IgE’s main purpose is to protect against parasites but due to improved sanitation these are no longer a prevalent issue across most of the world. Consequently it is thought that they become over activated and over sensitive while looking for parasites and start reacting to eg pollen and causing allergies.

IgA

Exists in serum in both monomeric (IgA1) and dimeric (IgA2) forms (dimeric when 2 Fcs bind via secretory complex)

15% of the total serum Ig.

4-7 day half life

Secretory IgA2 (dimer) = primary defense against some local infections

Secreted as a dimer in mucous (e.g., saliva, tears)

prevents passage of foreign substances into the circulatory system

Isotype: class of antibody (IgD, IgM etc)

Allotype: person specific alleles 

Idiotype: (hyper) variable region - antibody specificity